TMEM9

Across TCGA pan-cancer cohorts, TMEM9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM9 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM9 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, COAD, and HNSC are the cancer types where TMEM9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.075	<.001	11	view →
COAD	Female	All	+1.517	<.001	11	view →
HNSC	All	IV	+0.980	<.001	11	view →
LIHC	Male	All	+1.477	<.001	9	view →
KIRC	Female	IV	+0.716	<.001	8	view →
BLCA	Female	All	+1.211	.001	6	view →
BRCA	All	III,IV	+1.058	<.001	6	view →
UCEC	All	All	+0.778	<.001	6	view →
CHOL	Male	All	+2.486	<.001	5	view →
READ	All	All	+1.049	.002	5	view →
STAD	Male	II,III,IV	+0.947	<.001	4	view →
KIRP	Male	II,III,IV	+0.496	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM9–KICH

Open the KICH breakdown →