TMEM9

Across TCGA pan-cancer cohorts, TMEM9 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TMEM9 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM9 expression acts as an unfavorable survival marker, although some lineages such as DLBC and LUAD show a favorable association.

HNSC, UVM, and KICH are the cancer types where TMEM9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.278	0.441	<.001	115	view →
UVM	DFS	Tertile	II,III,IV	0.273	0.734	<.001	114	view →
KICH	DFS	Quartile	II,III,IV	0.249	0.942	<.001	105	view →
ACC	DFS	Median	All	0.206	0.733	<.001	91	view →
CESC	DFS	Median	All	0.650	0.823	<.001	84	view →
LIHC	OS	Tertile	All	0.598	0.781	<.001	66	view →
KIRP	DFS	Tertile	All	0.839	0.973	<.001	58	view →
BLCA	OS	Median	All	0.565	0.791	.002	54	view →
SCLC	DFS	Median	III,IV	0.207	0.516	.007	38	view →
DLBC	DFS	Quartile	II,III,IV	0.971	0.107	.010	30	view →
LGG	DFS	Median	All	0.648	0.848	<.001	24	view →
CHOL	DFS	Quartile	All	0.180	0.595	.019	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TMEM9–HNSC (DFS)

Open the HNSC breakdown →