TMEM9

Across TCGA cell cohorts, TMEM9 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM9-associated genes across cancer lineages are LGI1, AMELX, and TSHB. Each is linked with TMEM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM9-to-partner and partner-to-TMEM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by TMEM9-low versus TMEM9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM9→partner) and Y-score (partner→TMEM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	AMELX →	+0.028	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TSHB →	+0.229	+4.276	<.001	.007	3	1
BLOOD_Leukemia	LRIT1 →	+0.054	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	RGR →	+0.022	+5.269	.005	<.001	3	1
BLOOD_Leukemia	HTR5A →	+0.029	+4.409	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

LGI1 by TMEM9 expression — BLOOD_Leukemia

Explore this box plot interactively →