TMEM79

Across TCGA patient cohorts, TMEM79 mutation is significantly associated with the RNA expression of many other genes, with 913 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM79-associated genes across cancer lineages are MAB21L4, RN7SKP264, and TRPV2. Each is linked with TMEM79 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM79-to-partner and partner-to-TMEM79 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAB21L4 grouped by TMEM79-low versus TMEM79-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM79→partner) and Y-score (partner→TMEM79) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAB21L4 →	-1.334	-3.451	<.001	.005	3	2
LIHC	RN7SKP264 →	+0.122	+5.033	.001	.009	3	2
UCEC	TRPV2 →	+0.714	+3.467	<.001	.002	3	2
UCEC	BORCS6 →	+0.430	+2.839	.006	.001	3	2
UCEC	CD247 →	+0.943	+3.917	<.001	<.001	3	2
UCEC	TRAV26-1 →	+0.470	+2.839	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 913 associations by consensus.

MAB21L4 by TMEM79 expression — UCEC

Explore this box plot interactively →