TMEM79

Across TCGA pan-cancer cohorts, TMEM79 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMEM79 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM79 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM79 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCS show a favorable association.

KIRC, ACC, and LIHC are the cancer types where TMEM79 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.528	0.835	<.001	124	view →
ACC	DFS	Median	All	0.239	0.696	<.001	101	view →
LIHC	OS	Median	All	0.413	0.586	<.001	83	view →
LGG	DFS	Median	All	0.649	0.818	<.001	54	view →
KIRP	DFS	Tertile	All	0.437	0.669	.006	52	view →
SKCM	OS	Median	All	0.687	0.861	<.001	34	view →
LUSC	DFS	Median	II,III,IV	0.694	0.493	.001	33	view →
MESO	OS	Median	All	0.483	0.598	.015	24	view →
KICH	OS	Quartile	All	0.527	1.000	.002	14	view →
UCS	OS	Tertile	IV	0.766	0.311	.049	12	view →
COAD	DFS	Tertile	All	0.380	0.635	.022	11	view →
CHOL	DFS	Median	II,III,IV	0.112	0.542	.015	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMEM79–KIRC (DFS)

Open the KIRC breakdown →