TMEM74B

Across TCGA patient cohorts, TMEM74B mutation is significantly associated with the RNA expression of many other genes, with 1,781 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM74B-associated genes across cancer lineages are RN7SL255P, DHFRP3, and RNU6-225P. Each is linked with TMEM74B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM74B-to-partner and partner-to-TMEM74B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL255P grouped by TMEM74B-low versus TMEM74B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74B→partner) and Y-score (partner→TMEM74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL255P →	+0.241	+4.507	<.001	.001	3	2
LUAD	DHFRP3 →	+0.607	+4.712	<.001	.007	3	2
LUSC	RNU6-225P →	+0.166	+4.116	<.001	.009	3	2
UCEC	HSPD1P12 →	+0.162	+2.422	.002	.004	3	2
BRCA	H3P46 →	+0.193	+7.731	<.001	.009	3	1
BRCA	RBMY2KP →	+0.064	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,781 associations by consensus.

RN7SL255P by TMEM74B expression — CESC

Explore this box plot interactively →