TMEM74B

Across TCGA pan-cancer cohorts, TMEM74B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TMEM74B data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM74B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM74B expression acts as an unfavorable survival marker, although some lineages such as PAAD and READ show a favorable association.

KIRC, ESCA, and KIRP are the cancer types where TMEM74B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.432	0.618	<.001	139	view →
ESCA	OS	Median	All	0.582	0.806	<.001	54	view →
KIRP	DFS	Median	II,III,IV	0.291	0.873	.001	52	view →
UCEC	OS	Tertile	All	0.823	0.913	.004	50	view →
ACC	DFS	Median	All	0.359	0.751	.001	46	view →
UVM	DFS	Tertile	All	0.259	0.877	<.001	42	view →
PAAD	OS	Median	All	0.537	0.224	<.001	38	view →
READ	OS	Quartile	III,IV	0.874	0.413	.001	29	view →
UCS	OS	Tertile	All	0.561	0.828	.010	28	view →
SKCM	DFS	Quartile	III,IV	0.438	0.771	.008	27	view →
BLCA	OS	Quartile	II,III,IV	0.753	0.567	.013	19	view →
MESO	OS	Quartile	IV	0.333	0.758	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TMEM74B–KIRC (DFS)

Open the KIRC breakdown →