TMEM69

Across TCGA patient cohorts, TMEM69 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,552 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM69-associated proteins across cancer lineages are NASP, HAT1, and MCM7. Each is linked with TMEM69 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMEM69-to-partner and partner-to-TMEM69 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM69 versus NASP in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM69→partner) and Y-score (partner→TMEM69) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NASP →	+0.570	+0.246	.004	<.001	3	8
UCEC	HAT1 →	+0.427	+0.410	<.001	<.001	3	6
OV	MCM7 →	+0.662	+0.405	<.001	<.001	3	6
LSCC	MSH2 →	+0.387	+0.461	<.001	<.001	3	6
HNSC	YBX1 →	+0.391	+0.658	<.001	.004	3	6
OV	CDC20_T70 →	+1.207	+0.442	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,552 associations by consensus.

TMEM69 vs NASP — GBM

Explore this scatter interactively →