TMEM69

Across TCGA pan-cancer cohorts, TMEM69 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM69’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM69 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM69 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, BLCA, and LUSC are the cancer types where TMEM69 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM69 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.661	<.001	12	view →
BLCA	Male	All	+1.032	<.001	11	view →
LUSC	Female	All	+1.413	<.001	9	view →
LIHC	Male	II,III,IV	+1.201	<.001	9	view →
LUAD	Male	III,IV	+0.884	<.001	9	view →
STAD	Male	II,III,IV	+0.760	<.001	9	view →
KIRC	All	All	+0.202	.001	8	view →
KICH	Female	All	−1.095	<.001	7	view →
BRCA	All	III,IV	+0.409	<.001	6	view →
CHOL	All	All	+2.061	<.001	5	view →
UCEC	All	III,IV	+0.476	.047	2	view →
PRAD	All	All	+0.433	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM69–HNSC

Open the HNSC breakdown →