TMEM67

Across TCGA patient cohorts, TMEM67 protein abundance is significantly associated with the RNA expression of many other genes, with 2,530 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM67-associated genes across cancer lineages are EPS15L1, ANAPC1, and SNORD115-41. Each is linked with TMEM67 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM67-to-partner and partner-to-TMEM67 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM67 versus EPS15L1 in CCRCC, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM67→partner) and Y-score (partner→TMEM67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EPS15L1 →	-0.388	-0.787	.003	.004	3	3
UCEC	ANAPC1 →	-0.359	-0.291	.007	.005	3	3
CCRCC	SNORD115-41 →	-1.700	-1.078	.001	<.001	3	3
CCRCC	RREB1 →	-0.514	-0.955	<.001	<.001	3	2
LSCC	HNRNPD →	-0.383	-0.219	.006	.008	3	2
LSCC	ZNF791 →	-0.248	-0.208	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,530 associations by consensus.

TMEM67 vs EPS15L1 — CCRCC

Explore this scatter interactively →