TMEM65

Across TCGA patient cohorts, TMEM65 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM65-associated genes across cancer lineages are Gab2, MEK1_p_S217_S221, and Annexin-1. Each is linked with TMEM65 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM65-to-partner and partner-to-TMEM65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by TMEM65-low versus TMEM65-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM65→partner) and Y-score (partner→TMEM65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.538	+2.321	.001	.034	3	1
UCEC	MEK1_p_S217_S221 →	-0.325	-2.999	.010	.035	3	1
UCEC	Annexin-1 →	+0.680	+2.584	.005	.011	3	1
UCEC	VHL →	-1.107	-2.584	<.001	.010	3	1
UCEC	ATM →	-0.545	-3.156	.009	.018	3	1
UCEC	C-Raf →	+0.192	+3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Gab2 by TMEM65 expression — UCEC

Explore this box plot interactively →