TMEM65

Across TCGA pan-cancer cohorts, TMEM65 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM65’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM65 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM65 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where TMEM65 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM65 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.889	<.001	10	view →
BLCA	All	III,IV	+0.826	<.001	10	view →
LIHC	Male	All	+1.000	<.001	8	view →
STAD	All	II,III,IV	+0.847	<.001	8	view →
THCA	Female	All	−0.644	<.001	8	view →
LUSC	Female	All	+1.047	<.001	7	view →
KICH	All	All	+0.633	<.001	7	view →
LUAD	Male	All	+0.648	<.001	6	view →
CHOL	Female	All	+2.916	<.001	5	view →
BRCA	All	II,III,IV	+0.423	<.001	4	view →
READ	All	All	−0.578	.001	3	view →
KIRP	All	IV	+0.690	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM65–HNSC

Open the HNSC breakdown →