TMEM65

Across TCGA pan-cancer cohorts, TMEM65 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TMEM65 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TMEM65 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM65 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UVM, BRCA, and KIRP are the cancer types where TMEM65 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.271	0.869	<.001	104	view →
BRCA	OS	Median	All	0.899	0.949	<.001	78	view →
KIRP	DFS	Quartile	II,III,IV	0.260	0.755	<.001	72	view →
LIHC	OS	Quartile	All	0.545	0.777	<.001	65	view →
UCS	OS	Quartile	II,III,IV	0.612	0.189	.008	60	view →
CESC	DFS	Median	All	0.422	0.665	.002	44	view →
LUAD	OS	Quartile	All	0.252	0.551	<.001	42	view →
UCEC	DFS	Tertile	All	0.613	0.760	<.001	42	view →
SARC	OS	Tertile	All	0.395	0.839	<.001	31	view →
KIRC	DFS	Median	All	0.748	0.507	<.001	23	view →
THCA	DFS	Quartile	III,IV	0.395	0.879	.010	23	view →
STAD	DFS	Tertile	All	0.370	0.673	.014	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TMEM65–UVM (DFS)

Open the UVM breakdown →