TMEM65

Across TCGA cell cohorts, TMEM65 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,540 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM65-associated GO terms across cancer lineages are Phosphatidylinositol metabolic process, Positive regulation of GTPase activity, and Positive regulation of autophagosome assembly. Each is linked with TMEM65 in more than 9 cancer types. Because this analysis shows association rather than direction, both TMEM65-to-partner and partner-to-TMEM65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol metabolic process grouped by TMEM65-low versus TMEM65-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM65→partner) and Y-score (partner→TMEM65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Phosphatidylinositol metabolic process →	+0.051	+0.934	<.001	<.001	3	10
OVARY	Positive regulation of GTPase activity →	+0.040	+0.718	<.001	.001	3	9
STOMACH	Positive regulation of autophagosome assembly →	+0.071	+0.947	.005	.005	3	9
LIVER	Dephosphorylation →	+0.056	+0.952	<.001	.003	2	10
BONE	Regulation of angiotensin-activated signaling pathway →	+0.235	+1.070	<.001	<.001	2	9
PANCREAS	Insulin receptor signaling pathway →	+0.051	+0.713	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,540 associations by consensus.

Phosphatidylinositol metabolic process by TMEM65 expression — BONE

Explore this box plot interactively →