TMEM64

Across TCGA patient cohorts, TMEM64 mutation is significantly associated with the RNA expression of many other genes, with 3,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM64-associated genes across cancer lineages are RNU6-458P, UBTFL7, and MIR449B. Each is linked with TMEM64 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM64-to-partner and partner-to-TMEM64 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-458P grouped by TMEM64-low versus TMEM64-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM64→partner) and Y-score (partner→TMEM64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-458P →	+0.343	+7.954	<.001	.008	3	2
UCEC	UBTFL7 →	+0.119	+2.047	<.001	<.001	3	2
HNSC	MIR449B →	+0.453	+7.954	<.001	.008	3	1
UCEC	RPL23AP90 →	+0.229	+1.534	.005	.009	3	1
UCEC	ARF4P1 →	+0.482	+3.032	<.001	<.001	3	1
UCEC	IRF2-DT →	-0.449	-2.875	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,866 associations by consensus.

RNU6-458P by TMEM64 expression — HNSC

Explore this box plot interactively →