TMEM64

Across TCGA pan-cancer cohorts, TMEM64 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM64’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMEM64 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM64 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and HNSC are the cancer types where TMEM64 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM64 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.278	<.001	9	view →
LUAD	Female	II,III,IV	−1.067	<.001	9	view →
HNSC	All	III,IV	+0.725	<.001	9	view →
KICH	Female	All	−1.353	<.001	8	view →
KIRP	Female	II,III,IV	+0.755	.006	7	view →
UCEC	All	All	−1.456	<.001	6	view →
LIHC	Male	II,III,IV	+1.417	<.001	6	view →
KIRC	All	All	+0.224	.007	6	view →
LUSC	All	All	−0.538	<.001	4	view →
BRCA	Female	All	−0.407	.004	2	view →
PRAD	All	All	−0.334	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM64–THCA

Open the THCA breakdown →