TMEM61

Across TCGA patient cohorts, TMEM61 mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM61-associated genes across cancer lineages are MIR3158-1, MIR6877, and TRBV11-3. Each is linked with TMEM61 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM61-to-partner and partner-to-TMEM61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3158-1 grouped by TMEM61-low versus TMEM61-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM61→partner) and Y-score (partner→TMEM61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3158-1 →	+0.560	+5.103	<.001	.008	3	2
UCEC	MIR6877 →	+0.473	+2.563	.002	.005	3	2
UCEC	TRBV11-3 →	+0.380	+2.543	<.001	.004	3	2
UCEC	IL21 →	+0.136	+2.512	.004	.003	3	2
SKCM	RNY4P24 →	+0.410	+3.623	<.001	.006	3	2
SKCM	MRPS33P2 →	+0.097	+3.669	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

MIR3158-1 by TMEM61 expression — CESC

Explore this box plot interactively →