TMEM61

Across TCGA pan-cancer cohorts, TMEM61 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TMEM61 data layer compared with 8 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TMEM61 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM61 expression acts as an unfavorable survival marker, although some lineages such as COAD and LAML show a favorable association.

CESC, COAD, and LGG are the cancer types where TMEM61 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.616	0.851	<.001	64	view →
COAD	OS	Median	All	0.903	0.709	<.001	57	view →
LGG	OS	Median	All	0.714	0.903	<.001	54	view →
LUSC	OS	Quartile	II,III,IV	0.422	0.743	<.001	50	view →
UVM	DFS	Median	III,IV	0.164	0.918	<.001	40	view →
BLCA	OS	Median	II,III,IV	0.363	0.496	.015	33	view →
LIHC	OS	Quartile	All	0.617	0.808	.002	21	view →
LAML	DFS	Tertile	All	0.789	0.498	.022	18	view →
ACC	OS	Median	All	0.865	0.722	.008	15	view →
MESO	OS	Median	All	0.486	0.314	.021	12	view →
GBM	OS	Quartile	All	0.370	0.562	.012	10	view →
SKCM	OS	Quartile	II,III,IV	0.269	0.426	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TMEM61–CESC (DFS)

Open the CESC breakdown →