TMEM61

Across TCGA pan-cancer cohorts, TMEM61 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM61’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM61 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM61 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where TMEM61 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM61 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.827	<.001	12	view →
KIRP	Male	III,IV	−3.317	<.001	11	view →
COAD	Female	All	−1.486	<.001	9	view →
LUSC	Female	II,III,IV	−1.225	<.001	7	view →
LUAD	Male	All	+1.085	<.001	7	view →
HNSC	Male	All	−0.973	<.001	7	view →
BRCA	Female	II,III,IV	−0.614	<.001	6	view →
LIHC	All	All	+0.459	<.001	5	view →
CHOL	All	All	+2.608	<.001	3	view →
BLCA	Male	III,IV	−1.590	.017	2	view →
PAAD	All	All	+1.497	.038	2	view →
ESCA	Female	All	−1.380	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM61–KIRC

Open the KIRC breakdown →