TMEM59L

Across TCGA patient cohorts, TMEM59L mutation is significantly associated with the RNA expression of many other genes, with 1,527 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM59L-associated genes across cancer lineages are RNA5SP369, IL9, and RNU6-1082P. Each is linked with TMEM59L in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM59L-to-partner and partner-to-TMEM59L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by TMEM59L-low versus TMEM59L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59L→partner) and Y-score (partner→TMEM59L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP369 →	+0.349	+2.300	<.001	.001	3	3
CESC	IL9 →	+0.178	+4.276	<.001	.008	3	3
CESC	RNU6-1082P →	+0.229	+5.144	<.001	.003	3	3
SKCM	LINC00459 →	+0.057	+3.009	<.001	.009	3	3
UCEC	SETD3 →	+0.374	+2.513	.004	.001	3	2
UCEC	CIDECP1 →	+0.295	+2.053	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,527 associations by consensus.

RNA5SP369 by TMEM59L expression — UCEC

Explore this box plot interactively →