TMEM59L

Across TCGA pan-cancer cohorts, TMEM59L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM59L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM59L RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM59L is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRC are the cancer types where TMEM59L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM59L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.574	<.001	11	view →
KICH	Female	All	−1.219	<.001	10	view →
KIRC	All	II,III,IV	−0.632	<.001	10	view →
LUAD	Female	All	+1.825	<.001	7	view →
THCA	All	All	+1.434	<.001	6	view →
LIHC	All	All	+0.160	<.001	4	view →
BRCA	All	IV	+2.415	.030	2	view →
READ	Female	All	−2.134	<.001	2	view →
PRAD	All	All	+0.317	.027	2	view →
STAD	All	III,IV	−0.992	.032	1	view →
BLCA	Male	IV	−0.635	.025	1	view →
CHOL	All	All	+0.552	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM59L–COAD

Open the COAD breakdown →