TMEM59L

Across TCGA pan-cancer cohorts, TMEM59L RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TMEM59L data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TMEM59L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM59L expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

KIRP, ACC, and BLCA are the cancer types where TMEM59L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.528	0.804	<.001	138	view →
ACC	DFS	Median	All	0.218	0.702	<.001	86	view →
BLCA	OS	Tertile	II,III,IV	0.356	0.614	<.001	83	view →
COAD	DFS	Quartile	All	0.632	0.850	<.001	48	view →
LUSC	DFS	Tertile	III,IV	0.421	0.708	.004	46	view →
LGG	OS	Median	All	0.938	0.854	<.001	40	view →
HNSC	OS	Tertile	All	0.716	0.814	.001	34	view →
CESC	DFS	Quartile	All	0.742	0.907	.001	30	view →
OV	OS	Quartile	II,III,IV	0.310	0.465	<.001	26	view →
UCS	DFS	Tertile	IV	0.337	0.942	.024	24	view →
PAAD	OS	Quartile	All	0.653	0.254	.002	24	view →
UCEC	OS	Tertile	All	0.819	0.893	.014	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TMEM59L–KIRP (OS)

Open the KIRP breakdown →