TMEM59L

Across TCGA patient cohorts, TMEM59L mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM59L-associated genes across cancer lineages are Notch1, FOXO3a_pS318_S321, and Ku80. Each is linked with TMEM59L in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM59L-to-partner and partner-to-TMEM59L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TMEM59L-low versus TMEM59L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59L→partner) and Y-score (partner→TMEM59L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.179	+3.331	.004	.005	3	2
UCEC	FOXO3a_pS318_S321 →	-0.169	-2.700	.002	.006	3	1
UCEC	Ku80 →	+0.321	+2.713	.002	.003	3	1
UCEC	MEK1 →	+0.482	+2.700	.003	.006	3	1
UCEC	mTOR_pS2448 →	-0.132	-2.000	.049	.032	3	1
UCEC	p62 Lck ligand →	+0.517	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by TMEM59L expression — UCEC

Explore this box plot interactively →