TMEM59L

Across TCGA cell cohorts, TMEM59L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,013 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM59L-associated GO terms across cancer lineages are Thigmotaxis, Regulation of myoblast fusion, and Negative regulation of motor neuron apoptotic process. Each is linked with TMEM59L in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM59L-to-partner and partner-to-TMEM59L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Thigmotaxis grouped by TMEM59L-low versus TMEM59L-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59L→partner) and Y-score (partner→TMEM59L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Thigmotaxis →	+0.221	+1.417	.009	.001	3	12
BONE	Regulation of myoblast fusion →	+0.079	+1.957	<.001	<.001	3	11
LIVER	Negative regulation of motor neuron apoptotic process →	+0.304	+2.071	<.001	.001	3	10
STOMACH	Negative regulation of myoblast fusion →	+0.111	+1.317	.005	.009	3	9
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.153	+1.609	<.001	.007	2	10
LIVER	Negative regulation of interferon-alpha production →	+1.732	+1.558	<.001	.009	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,013 associations by consensus.

Thigmotaxis by TMEM59L expression — SKIN

Explore this box plot interactively →