TMEM59L

Across TCGA cell cohorts, TMEM59L mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM59L-associated genes across cancer lineages are MSGN1 and TAFA1. Each is linked with TMEM59L in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM59L-to-partner and partner-to-TMEM59L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by TMEM59L-low versus TMEM59L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59L→partner) and Y-score (partner→TMEM59L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.126	+4.930	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MSGN1 by TMEM59L expression — LARGE_INTESTINE

Explore this box plot interactively →