TMEM59L

Across TCGA cell cohorts, TMEM59L mutation is significantly associated with the mutation status of many other genes, with 1,166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM59L-associated genes across cancer lineages are GABRG3, KIAA0930, and PHEX. Each is linked with TMEM59L in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM59L-to-partner and partner-to-TMEM59L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRG3 grouped by TMEM59L-low versus TMEM59L-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59L→partner) and Y-score (partner→TMEM59L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GABRG3 →	+4.437	+5.000	.007	.007	1	2
LARGE_INTESTINE	KIAA0930 →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	PHEX →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	NPRL3 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	TBC1D10A →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	ERCC8 →	+3.087	+4.392	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,166 associations by consensus.

GABRG3 by TMEM59L expression — BONE

Explore this box plot interactively →