TMEM52

Across TCGA patient cohorts, TMEM52 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,384 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TMEM52-associated proteins across cancer lineages are THOC5, POLR1A, and XRCC6_T455. Each is linked with TMEM52 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM52-to-partner and partner-to-TMEM52 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM52 versus THOC5 in LSCC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM52→partner) and Y-score (partner→TMEM52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	THOC5 →	+0.249	+0.793	<.001	<.001	3	5
LSCC	POLR1A →	+0.289	+0.889	<.001	<.001	3	5
LSCC	XRCC6_T455 →	+0.563	+0.726	.001	<.001	3	4
LUAD	YY1AP1_S724 →	+0.436	+0.674	<.001	<.001	3	4
UCEC	ZC3H14_S515 →	+0.348	+0.599	<.001	.002	3	4
LSCC	ZCCHC8 →	+0.226	+0.709	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,384 associations by consensus.

TMEM52 vs THOC5 — LSCC

Explore this scatter interactively →