TMEM52

Across TCGA pan-cancer cohorts, TMEM52 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM52 data layer compared with 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM52 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM52 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

UCEC, LUAD, and COAD are the cancer types where TMEM52 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.764	0.879	.004	112	view →
LUAD	DFS	Tertile	All	0.854	0.694	.002	82	view →
COAD	DFS	Median	All	0.400	0.706	<.001	80	view →
UVM	DFS	Tertile	II,III,IV	0.304	0.644	.002	51	view →
KICH	OS	Quartile	III,IV	0.253	0.827	.005	28	view →
PAAD	OS	Tertile	All	0.309	0.638	.005	25	view →
LIHC	DFS	Median	All	0.462	0.621	<.001	24	view →
GBM	OS	Quartile	All	0.295	0.472	.003	21	view →
UCS	DFS	Quartile	II,III,IV	0.610	0.145	.012	18	view →
MESO	OS	Quartile	IV	0.122	0.889	.006	15	view →
ESCA	DFS	Quartile	III,IV	0.297	0.578	.028	10	view →
BRCA	DFS	Quartile	II,III,IV	0.927	0.851	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM52–UCEC (DFS)

Open the UCEC breakdown →