TMEM52

Across TCGA pan-cancer cohorts, TMEM52 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM52’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM52 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM52 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

COAD, LUAD, and KIRP are the cancer types where TMEM52 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM52 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.447	<.001	11	view →
LUAD	All	III,IV	+1.432	<.001	11	view →
KIRP	Female	All	−1.184	<.001	11	view →
THCA	Male	III,IV	−0.592	<.001	11	view →
LUSC	Male	II,III,IV	+1.516	<.001	9	view →
BLCA	All	IV	+1.210	<.001	9	view →
KIRC	Male	All	−0.497	<.001	9	view →
HNSC	Male	All	−1.539	<.001	8	view →
UCEC	All	All	+1.562	<.001	6	view →
STAD	All	II,III,IV	+1.242	.001	5	view →
BRCA	All	All	+0.264	.024	4	view →
READ	All	All	+1.002	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM52–COAD

Open the COAD breakdown →