TMEM52

Across TCGA patient cohorts, TMEM52 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM52-associated genes across cancer lineages are JNK2, Ku80, and p38-MAPK_pT180_Y182. Each is linked with TMEM52 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM52-to-partner and partner-to-TMEM52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TMEM52-low versus TMEM52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM52→partner) and Y-score (partner→TMEM52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.289	+2.817	.005	.036	3	1
UCEC	Ku80 →	+0.251	+2.183	.042	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.680	-3.000	.003	.036	3	1
UCEC	PCNA →	+0.377	+2.999	<.001	.035	3	1
UCEC	Annexin-1 →	+0.724	+2.827	.008	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.745	+3.019	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by TMEM52 expression — UCEC

Explore this box plot interactively →