TMEM52

Across TCGA cell cohorts, TMEM52 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,083 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM52-associated GO terms across cancer lineages are mRNA modification, Pseudouridine synthesis, and rRNA pseudouridine synthesis. Each is linked with TMEM52 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM52-to-partner and partner-to-TMEM52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA modification grouped by TMEM52-low versus TMEM52-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM52→partner) and Y-score (partner→TMEM52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	mRNA modification →	+0.112	+1.801	<.001	<.001	3	12
BONE	Pseudouridine synthesis →	+0.098	+1.351	<.001	.001	3	10
BONE	rRNA pseudouridine synthesis →	+0.124	+1.501	.001	.006	3	10
BONE	Amino acid metabolic process →	+0.073	+1.569	<.001	<.001	3	10
BONE	Malate transmembrane transport →	+0.301	+2.087	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Small GTPase-mediated signal transduction →	-0.057	-1.153	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,083 associations by consensus.

mRNA modification by TMEM52 expression — BONE

Explore this box plot interactively →