TMEM45A

Across TCGA patient cohorts, TMEM45A protein abundance is significantly associated with the RNA expression of many other genes, with 4,746 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM45A-associated genes across cancer lineages are MIF4GD, IRF4, and KLRG1. Each is linked with TMEM45A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM45A-to-partner and partner-to-TMEM45A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM45A versus MIF4GD in LSCC, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM45A→partner) and Y-score (partner→TMEM45A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MIF4GD →	-0.660	-1.085	.002	.005	3	2
LSCC	IRF4 →	+1.693	+1.093	<.001	.007	3	2
LSCC	KLRG1 →	+1.188	+1.560	.002	.002	3	2
LSCC	ADAMTS16 →	+1.161	+1.029	<.001	.002	3	2
LSCC	TLCD1 →	-0.847	-1.195	.003	.005	3	2
OV	SPRYD4 →	-1.256	-0.943	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,746 associations by consensus.

TMEM45A vs MIF4GD — LSCC

Explore this scatter interactively →