TMEM45A

Across TCGA cell cohorts, TMEM45A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM45A-associated genes across cancer lineages are TNP1, ZNF831, and TAFA1. Each is linked with TMEM45A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM45A-to-partner and partner-to-TMEM45A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by TMEM45A-low versus TMEM45A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM45A→partner) and Y-score (partner→TMEM45A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.160	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1
LUNG_NSCLC_LUAD	SIGLEC8 →	+0.025	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPINK8 →	+0.591	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TNP1 by TMEM45A expression — LARGE_INTESTINE

Explore this box plot interactively →