TMEM38B

Across TCGA patient cohorts, TMEM38B mutation is significantly associated with the RNA expression of many other genes, with 1,251 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM38B-associated genes across cancer lineages are RNU6-633P, RNU6-1127P, and MIR5190. Each is linked with TMEM38B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM38B-to-partner and partner-to-TMEM38B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-633P grouped by TMEM38B-low versus TMEM38B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM38B→partner) and Y-score (partner→TMEM38B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-633P →	+0.398	+3.789	.001	.004	3	2
COAD	RNU6-1127P →	+0.351	+4.721	<.001	.004	3	2
COAD	MIR5190 →	+0.658	+4.080	.002	.002	3	2
UCEC	AGO1 →	+0.403	+2.609	.004	.006	3	2
UCEC	NUP50 →	+0.434	+2.721	.002	.003	3	2
LUSC	RNU6-310P →	+0.330	+5.474	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,251 associations by consensus.

RNU6-633P by TMEM38B expression — COAD

Explore this box plot interactively →