TMEM38B

Across TCGA pan-cancer cohorts, TMEM38B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM38B’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TMEM38B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM38B is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

LIHC, HNSC, and STAD are the cancer types where TMEM38B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM38B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+1.356	<.001	9	view →
HNSC	All	II,III,IV	+0.673	<.001	9	view →
STAD	All	II,III,IV	+1.054	<.001	8	view →
THCA	All	All	−0.612	<.001	7	view →
KIRP	Male	All	−0.987	<.001	6	view →
KICH	All	All	−1.254	<.001	4	view →
CHOL	Male	All	+0.708	<.001	4	view →
COAD	All	II,III,IV	+0.503	.004	4	view →
BRCA	All	II,III,IV	+0.261	.021	4	view →
LUSC	Male	All	+0.724	<.001	3	view →
UCEC	All	All	−1.186	<.001	2	view →
ESCA	All	All	+1.137	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM38B–LIHC

Open the LIHC breakdown →