TMEM35A

Across TCGA patient cohorts, TMEM35A mutation is significantly associated with the RNA expression of many other genes, with 1,927 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM35A-associated genes across cancer lineages are RNU6-756P, NGRN, and RPL23AP82. Each is linked with TMEM35A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM35A-to-partner and partner-to-TMEM35A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-756P grouped by TMEM35A-low versus TMEM35A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM35A→partner) and Y-score (partner→TMEM35A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-756P →	+0.333	+7.640	<.001	.009	3	2
UCEC	NGRN →	+0.567	+2.928	<.001	<.001	3	2
UCEC	RPL23AP82 →	+0.405	+2.684	<.001	<.001	3	2
UCEC	PINCR →	+0.179	+1.863	<.001	<.001	3	2
UCEC	MTFP1 →	+0.464	+2.917	.003	<.001	3	2
UCEC	SYNJ2BP-COX16 →	+0.177	+2.295	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,927 associations by consensus.

RNU6-756P by TMEM35A expression — BLCA

Explore this box plot interactively →