TMEM35A

Across TCGA pan-cancer cohorts, TMEM35A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM35A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TMEM35A RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM35A is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KIRP are the cancer types where TMEM35A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM35A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.882	<.001	11	view →
COAD	Male	II,III,IV	−2.729	<.001	11	view →
KIRP	All	III,IV	−0.838	<.001	9	view →
THCA	Female	II,III,IV	−0.768	<.001	9	view →
STAD	Female	All	−3.201	<.001	8	view →
LUSC	Female	III,IV	−2.300	<.001	8	view →
LUAD	Female	III,IV	−1.896	<.001	8	view →
READ	All	All	−3.749	<.001	7	view →
KIRC	Male	II,III,IV	−0.682	<.001	7	view →
UCEC	All	All	−1.264	.001	6	view →
BRCA	Female	II,III,IV	−0.967	<.001	6	view →
LIHC	Female	II,III,IV	+0.075	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM35A–BLCA

Open the BLCA breakdown →