TMEM259

Across TCGA cell cohorts, TMEM259 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM259-associated genes across cancer lineages are OR2M5, OR14C36, and OR11L1. Each is linked with TMEM259 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM259-to-partner and partner-to-TMEM259 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by TMEM259-low versus TMEM259-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM259→partner) and Y-score (partner→TMEM259) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR2M5 →	+0.044	+5.321	<.001	.005	3	1
CNS	OR14C36 →	+0.049	+5.754	<.001	.002	3	1
CNS	OR11L1 →	+0.021	+4.981	<.001	.008	3	1
CNS	OR5H6 →	+0.018	+4.981	<.001	.008	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR2M5 by TMEM259 expression — CNS

Explore this box plot interactively →