TMEM259

Across TCGA pan-cancer cohorts, TMEM259 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM259’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM259 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM259 is over-expressed in tumor.

HNSC, COAD, and KIRC are the cancer types where TMEM259 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM259 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.626	<.001	11	view →
COAD	Female	All	+0.748	<.001	10	view →
KIRC	Female	All	+0.466	<.001	10	view →
BLCA	All	All	+0.535	<.001	9	view →
LIHC	Female	II,III,IV	+0.739	<.001	7	view →
STAD	Male	II,III,IV	+0.797	<.001	6	view →
KIRP	Female	II,III,IV	+0.605	.011	4	view →
LUSC	Male	All	+0.259	.015	4	view →
CHOL	Female	All	+1.466	<.001	3	view →
ESCA	All	All	+0.528	.034	1	view →
READ	All	All	+0.517	.026	1	view →
KICH	All	II,III,IV	+0.332	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM259–HNSC

Open the HNSC breakdown →