TMEM256-PLSCR3

Across TCGA cell cohorts, TMEM256-PLSCR3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM256-PLSCR3-associated genes across cancer lineages are GHRH, OR10W1, and MMP27. Each is linked with TMEM256-PLSCR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM256-PLSCR3-to-partner and partner-to-TMEM256-PLSCR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by TMEM256-PLSCR3-low versus TMEM256-PLSCR3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM256-PLSCR3→partner) and Y-score (partner→TMEM256-PLSCR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+5.562	<.001	<.001	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GHRH by TMEM256-PLSCR3 expression — OESOPHAGUS

Explore this box plot interactively →