TMEM256-PLSCR3

Across TCGA pan-cancer cohorts, TMEM256-PLSCR3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM256-PLSCR3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TMEM256-PLSCR3 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM256-PLSCR3 is over-expressed in tumor, although a few such as LUAD and LIHC show the opposite, repressed pattern.

LUAD, LIHC, and KIRP are the cancer types where TMEM256-PLSCR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM256-PLSCR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.118	<.001	9	view →
LIHC	Female	All	−0.074	<.001	8	view →
KIRP	Female	All	+0.186	<.001	7	view →
BRCA	All	All	−0.112	<.001	6	view →
KIRC	Male	All	+0.052	<.001	6	view →
THCA	Male	II,III,IV	−0.088	.001	5	view →
UCEC	All	All	−0.164	<.001	4	view →
HNSC	Female	All	+0.065	.006	3	view →
KICH	All	All	−0.109	.001	2	view →
READ	Female	All	−0.074	.036	1	view →
STAD	All	All	−0.070	.027	1	view →
LUSC	All	All	−0.041	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM256-PLSCR3–LUAD

Open the LUAD breakdown →