TMEM256-PLSCR3

Across TCGA pan-cancer cohorts, TMEM256-PLSCR3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TMEM256-PLSCR3 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher TMEM256-PLSCR3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM256-PLSCR3 expression acts as an unfavorable survival marker, although some lineages such as PAAD and KIRC show a favorable association.

THCA, PAAD, and LUAD are the cancer types where TMEM256-PLSCR3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	III,IV	0.479	0.865	.001	54	view →
PAAD	OS	Median	All	0.511	0.283	.002	48	view →
LUAD	DFS	Quartile	III,IV	0.257	0.667	<.001	35	view →
KIRC	DFS	Median	All	0.738	0.531	.002	28	view →
KICH	DFS	Quartile	All	0.329	1.000	.001	23	view →
ESCA	OS	Tertile	II,III,IV	0.843	0.641	.008	19	view →
BRCA	OS	Tertile	III,IV	0.911	0.763	.003	17	view →
UCS	DFS	Tertile	IV	0.296	0.829	.024	16	view →
OV	OS	Quartile	All	0.777	0.881	.008	16	view →
MESO	OS	Median	IV	0.392	0.771	.010	13	view →
ACC	DFS	Quartile	All	0.395	0.846	.011	13	view →
DLBC	OS	Median	All	0.503	1.000	.020	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TMEM256-PLSCR3–THCA (DFS)

Open the THCA breakdown →