TMEM249

Across TCGA patient cohorts, TMEM249 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM249-associated genes across cancer lineages are RNU6-206P, IGHD1-26, and DUTP5. Each is linked with TMEM249 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM249-to-partner and partner-to-TMEM249 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-206P grouped by TMEM249-low versus TMEM249-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM249→partner) and Y-score (partner→TMEM249) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-206P →	+0.564	+6.245	<.001	<.001	3	1
UCEC	IGHD1-26 →	+1.391	+4.484	<.001	.009	3	1
UCEC	DUTP5 →	+0.287	+4.349	<.001	.007	3	1
UCEC	MIR1266 →	+0.429	+4.771	<.001	.006	3	1
UCEC	GRPEL2P2 →	+0.165	+4.661	.001	.004	3	1
UCEC	PPP1R2P5 →	+0.134	+5.027	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RNU6-206P by TMEM249 expression — UCEC

Explore this box plot interactively →