TMEM249

Across TCGA pan-cancer cohorts, TMEM249 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM249’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM249 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM249 is over-expressed in tumor.

COAD, HNSC, and BLCA are the cancer types where TMEM249 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM249 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.875	<.001	12	view →
HNSC	Male	All	+0.190	<.001	10	view →
BLCA	All	All	+0.443	.002	9	view →
LUAD	All	II,III,IV	+0.277	<.001	9	view →
LIHC	All	All	+0.072	<.001	9	view →
READ	Female	All	+0.968	<.001	6	view →
UCEC	All	All	+0.423	<.001	6	view →
LUSC	Male	II,III,IV	+0.330	<.001	6	view →
STAD	All	II,III,IV	+0.318	<.001	6	view →
BRCA	All	III,IV	+0.316	<.001	6	view →
KIRC	All	All	+0.026	.003	3	view →
CHOL	Female	All	+0.140	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM249–COAD

Open the COAD breakdown →