TMEM245

Across TCGA cell cohorts, TMEM245 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM245-associated genes across cancer lineages are DMRTB1, GSTA3, and OR2T4. Each is linked with TMEM245 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM245-to-partner and partner-to-TMEM245 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTB1 grouped by TMEM245-low versus TMEM245-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM245→partner) and Y-score (partner→TMEM245) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DMRTB1 →	+0.023	+4.108	.004	.005	3	1
LUNG_NSCLC_LUSC	GSTA3 →	+0.037	+4.108	.007	.005	3	1
SKIN	OR2T4 →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	OR2AK2 →	+0.053	+4.191	<.001	.007	3	1
LARGE_INTESTINE	FMO1 →	+0.111	+3.921	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

DMRTB1 by TMEM245 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →