TMEM245

Across TCGA pan-cancer cohorts, TMEM245 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM245’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM245 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM245 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where TMEM245 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM245 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.063	<.001	12	view →
HNSC	All	III,IV	+0.760	<.001	11	view →
THCA	Male	All	−0.716	<.001	9	view →
LIHC	Male	II,III,IV	+1.260	<.001	8	view →
LUAD	Female	III,IV	−1.183	<.001	8	view →
LUSC	Male	All	−0.826	<.001	7	view →
UCEC	All	All	−1.834	<.001	6	view →
BLCA	Male	All	−0.996	.002	6	view →
BRCA	Female	All	−0.687	<.001	6	view →
KICH	Male	All	−1.198	<.001	5	view →
CHOL	All	All	+1.392	<.001	2	view →
STAD	Female	All	−0.941	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM245–KIRC

Open the KIRC breakdown →