TMEM236

Across TCGA patient cohorts, TMEM236 mutation is significantly associated with the RNA expression of many other genes, with 2,767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM236-associated genes across cancer lineages are PSMC2P2, TEMN3-AS1, and MIR4325. Each is linked with TMEM236 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM236-to-partner and partner-to-TMEM236 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC2P2 grouped by TMEM236-low versus TMEM236-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM236→partner) and Y-score (partner→TMEM236) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PSMC2P2 →	+0.039	+4.314	<.001	.009	3	2
LUAD	TEMN3-AS1 →	+0.501	+4.612	<.001	.006	3	2
LUAD	MIR4325 →	+0.235	+6.339	<.001	<.001	3	2
LUSC	CIR1P3 →	+0.062	+4.853	.007	.004	3	2
LUSC	MTND4P25 →	+0.056	+5.148	.001	.002	3	2
UCEC	PHBP15 →	+0.026	+3.245	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,767 associations by consensus.

PSMC2P2 by TMEM236 expression — BLCA

Explore this box plot interactively →