TMEM236

Across TCGA pan-cancer cohorts, TMEM236 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TMEM236 data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher TMEM236 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM236 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

UVM, LUSC, and STAD are the cancer types where TMEM236 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.267	0.648	.002	63	view →
LUSC	DFS	Quartile	II,III,IV	0.206	0.761	<.001	63	view →
STAD	OS	Median	II,III,IV	0.566	0.846	<.001	47	view →
SKCM	DFS	Quartile	III,IV	0.695	0.396	.002	40	view →
BLCA	DFS	Median	II,III,IV	0.425	0.233	.008	37	view →
UCS	DFS	Tertile	IV	0.818	0.237	.024	34	view →
LIHC	OS	Tertile	All	0.436	0.680	<.001	34	view →
LGG	OS	Median	All	0.866	0.748	<.001	34	view →
LUAD	OS	Tertile	All	0.717	0.604	.011	16	view →
COAD	DFS	Quartile	II,III,IV	0.817	0.567	.010	14	view →
PAAD	DFS	Tertile	All	0.476	0.217	.004	13	view →
CHOL	DFS	Median	II,III,IV	0.633	0.128	.031	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TMEM236–UVM (DFS)

Open the UVM breakdown →