TMEM218

Across TCGA patient cohorts, TMEM218 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM218-associated genes across cancer lineages are SPDYE8, MIR4255, and OR2T7. Each is linked with TMEM218 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM218-to-partner and partner-to-TMEM218 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPDYE8 grouped by TMEM218-low versus TMEM218-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM218→partner) and Y-score (partner→TMEM218) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPDYE8 →	+0.014	+8.471	<.001	.005	3	1
BRCA	MIR4255 →	+0.922	+8.055	<.001	.007	3	1
COAD	OR2T7 →	+0.098	+7.741	<.001	.009	3	1
COAD	USP9YP1 →	+0.069	+7.741	<.001	.009	3	1
UCEC	MIR4537 →	+1.476	+4.370	<.001	<.001	3	1
UCEC	MIR3909 →	+0.402	+3.156	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

SPDYE8 by TMEM218 expression — BRCA

Explore this box plot interactively →