TMEM205

Across TCGA patient cohorts, TMEM205 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM205-associated genes across cancer lineages are RN7SKP290, RNU6-90P, and MIR6769A. Each is linked with TMEM205 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM205-to-partner and partner-to-TMEM205 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP290 grouped by TMEM205-low versus TMEM205-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM205→partner) and Y-score (partner→TMEM205) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP290 →	+0.240	+3.136	.004	.008	3	1
UCEC	RNU6-90P →	+0.499	+2.512	.006	.007	3	1
UCEC	MIR6769A →	+0.737	+3.397	.002	<.001	3	1
UCEC	GPR157 →	+1.051	+3.201	.003	.009	3	1
UCEC	BRF1 →	+0.464	+3.226	.002	.009	3	1
UCEC	RNU6-280P →	+0.210	+4.245	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

RN7SKP290 by TMEM205 expression — UCEC

Explore this box plot interactively →